Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 8/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | CLK3 | P49761 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.31 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749206 | 0.88 | KDM2B (0.42) | MC4RKDM2BNTRK1GSK3BRXFP1 | |
| SCHEMBL4749161 | 0.78 | KDM2B (0.38) | MC4RKDM2BMCHR1NTRK1KCNH2 | |
| SCHEMBL4021139 | 0.76 | KDM2B (0.43) | MC4RKDM2BMCHR1SMN1; SMN2 | |
| SCHEMBL4026436 | 0.75 | KDM2B (0.42) | MC4RKDM2BMCHR1THRBSMN1; SMN2 | |
| SCHEMBL4020026 | 0.75 | KDM2B (0.42) | MC4RKDM2BMCHR1SMN1; SMN2 | |
| SCHEMBL4026512 | 0.74 | NPC1 (0.41) | MC4RKDM2BNTRK1 | |
| SCHEMBL4780053 | 0.73 | MC4R (0.44) | MC4RNTRK1NTRK3NTRK2 | |
| SCHEMBL4749342 | 0.73 | KDM2B (0.40) | MC4RKDM2BMCHR1 | |
| SCHEMBL4024597 | 0.72 | KDM2B (0.45) | KDM2BSMN1; SMN2 | |
| SCHEMBL4021398 | 0.72 | KDM2B (0.45) | KDM2BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | claimed |
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |