Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 3/20 | 0.45 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749720 | 0.88 | TP53 (0.50) | SMN1; SMN2TP53PKMBACE1CTSD | |
| SCHEMBL475666 | 0.81 | MCHR1 (0.58) | SMN1; SMN2TP53PKMBACE1NPC1 | |
| SCHEMBL475723 | 0.80 | LCK (0.45) | SMN1; SMN2BACE1NPC1RAB9AL3MBTL1 | |
| SCHEMBL17373856 | 0.77 | NAAA (0.68) | SMN1; SMN2L3MBTL1NAAACA2THRA | |
| SCHEMBL17373956 | 0.77 | NAAA (0.68) | SMN1; SMN2L3MBTL1NAAACA2THRA | |
| SCHEMBL4750118 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1KDM4ENAAALMNA | |
| SCHEMBL2914113 | 0.77 | SMN1; SMN2 (0.79) | SMN1; SMN2L3MBTL1NAAATSHRHTT | |
| SCHEMBL3446746 | 0.76 | RAB9A (0.39) | SMN1; SMN2TP53BACE1CTSDBACE2 | |
| SCHEMBL6648153 | 0.75 | NAAA (0.56) | SMN1; SMN2L3MBTL1NAAACA2GPR84 | |
| SCHEMBL3863169 | 0.75 | RAB9A (0.38) | SMN1; SMN2BACE1CTSDBACE2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119772-A1 | AMIDE DERIVATIVES AS INHIBITORS OF ASPARTYL PROTEASES | MEDIVIR AB (SE) | 2008-10-09 | — | — | WO | disclosed |