Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749868 | 0.87 | BRAF (0.67) | BRAFCYP2C9LCKBTKKDR | |
| SCHEMBL4750556 | 0.86 | BRAF (0.67) | BRAFCYP2C9LCKBTK | |
| SCHEMBL5803018 | 0.86 | BRAF (0.54) | BRAFCYP2C9LCKMAPK14 | |
| SCHEMBL4970779 | 0.85 | NR1H4 (0.49) | BRAFCYP2C9 | |
| SCHEMBL5802387 | 0.84 | BRAF (0.45) | BRAFCYP2C9LCKBTK | |
| SCHEMBL5799643 | 0.84 | BRAF (0.49) | BRAFCYP2C9BTKMAPK14 | |
| SCHEMBL5801432 | 0.83 | BRAF (0.52) | BRAFCYP2C9LCKBTKKDR | |
| SCHEMBL4966996 | 0.80 | ROCK2 (0.44) | BRAFMAPK14 | |
| SCHEMBL3934670 | 0.79 | BRAF (0.88) | BRAFCYP2C9LCKBTKKDR | |
| SCHEMBL5212609 | 0.76 | MAPT (0.52) | CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008120004-A1 | COMBINATION OF A MEK- INHIBITOR AND A B-RAF INHIBITOR FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | WO | claimed |