Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4750077 | 0.83 | BRAF (0.57) | BRAFCYP2C9KDRMAPK14LCK | |
| SCHEMBL3940366 | 0.82 | BRAF (0.77) | BRAFCYP2C9KITKDRMAPK14 | |
| SCHEMBL4970779 | 0.81 | NR1H4 (0.49) | BRAFCYP2C9 | |
| SCHEMBL4749868 | 0.80 | BRAF (0.67) | BRAFCYP2C9KDRMAPK14LCK | |
| SCHEMBL4750556 | 0.79 | BRAF (0.67) | BRAFCYP2C9LCKBTKCSF1R | |
| SCHEMBL5803018 | 0.78 | BRAF (0.54) | BRAFCYP2C9KITMAPK14LCK | |
| SCHEMBL5802387 | 0.77 | BRAF (0.45) | BRAFCYP2C9LCKBTK | |
| SCHEMBL4966996 | 0.74 | ROCK2 (0.44) | BRAFMAPK14ALDH1A1MAPT | |
| SCHEMBL5799643 | 0.73 | BRAF (0.49) | BRAFCYP2C9MAPK14BTKCSF1R | |
| SCHEMBL3932957 | 0.72 | BRAF (0.76) | BRAFCYP2C9KDRMAPK14LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006067445-A2 | CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |