Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.49 |
| ▸ | BRAF | P15056 | 12/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CASR | P41180 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966996 | 0.86 | ROCK2 (0.44) | BRAFKMT2AMEN1KCNK3KCNK9 | |
| SCHEMBL4750077 | 0.85 | BRAF (0.57) | BRAFCYP2C9 | |
| SCHEMBL5803018 | 0.83 | BRAF (0.54) | BRAFCYP2C9 | |
| SCHEMBL5212609 | 0.82 | MAPT (0.52) | KMT2AMEN1SIRT3CYP2C9SMN1; SMN2 | |
| SCHEMBL4750556 | 0.82 | BRAF (0.67) | BRAFCYP2C9 | |
| SCHEMBL4749868 | 0.81 | BRAF (0.67) | BRAFCYP2C9 | |
| SCHEMBL5801432 | 0.81 | BRAF (0.52) | BRAFCYP2C9 | |
| SCHEMBL5800552 | 0.81 | MEN1 (0.53) | KMT2AMEN1CYP2C9CASRSMN1; SMN2 | |
| SCHEMBL5212161 | 0.79 | MAPK14 (0.47) | BRAFKMT2AMEN1 | |
| SCHEMBL5802387 | 0.78 | BRAF (0.45) | BRAFCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966174-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007071955-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | disclosed |