Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.49 |
| ▸ | CSF1R | P07333 | 13/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749868 | 0.85 | BRAF (0.67) | BRAFCSF1RCYP2C9JAK2PDGFRB | |
| SCHEMBL4750077 | 0.84 | BRAF (0.57) | BRAFCYP2C9MAPK14BTK | |
| SCHEMBL3934465 | 0.80 | BRAF (0.75) | BRAFCSF1RCYP2C9JAK2PDGFRB | |
| SCHEMBL5800552 | 0.80 | MEN1 (0.53) | CSF1RCYP2C9 | |
| SCHEMBL4966996 | 0.80 | ROCK2 (0.44) | BRAFMAPK14 | |
| SCHEMBL3936637 | 0.76 | BRAF (0.51) | BRAFCSF1RCYP2C9JAK2PDGFRB | |
| SCHEMBL4750556 | 0.76 | BRAF (0.67) | BRAFCSF1RCYP2C9BTK | |
| SCHEMBL4970779 | 0.75 | NR1H4 (0.49) | BRAFCYP2C9 | |
| SCHEMBL5803018 | 0.75 | BRAF (0.54) | BRAFCSF1RCYP2C9MAPK14 | |
| SCHEMBL4749967 | 0.74 | BRAF (0.57) | BRAFCSF1RCYP2C9JAK2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006067445-A2 | CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |