SCHEMBL4750229

SCHEMBL4750229

CCn1ccc2cc(-c3ccccc3)nc(C)c2c1=O

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 3/20 0.45
PDE5A O76074 1/20 0.44
ALDH1A1 P00352 5/20 0.43
KDM4E B2RXH2 2/20 0.43
MAPK1 P28482 1/20 0.43
GRM2 Q14416 5/20 0.40
CYP11B1 P15538 2/20 0.40
TSHR P16473 1/20 0.40
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
ADORA2A P29274 1/20 0.39
CYP17A1 P05093 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4245537 0.87 ADORA2A (0.51) PDE5AALDH1A1KDM4EADORA2A
SCHEMBL5816274 0.87 ALDH1A1 (0.43) ALDH1A1KDM4EMAPK1GRM2MAPT
SCHEMBL4751098 0.82 GRM2 (0.38) ALDH1A1GRM2MAPT
SCHEMBL4248495 0.82 ALDH1A1 (0.47) PDE5AALDH1A1KDM4EGAAMAPT
SCHEMBL4750004 0.80 GRM2 (0.39) ALDH1A1KDM4EMAPK1GRM2
SCHEMBL4747892 0.75 ALDH1A1 (0.42) ALDH1A1KDM4EGAAMAPTSMN1; SMN2
SCHEMBL4747889 0.74 ALDH1A1 (0.40) PDE5AALDH1A1KDM4EMAPK1GAA
SCHEMBL5816238 0.74 ALDH1A1 (0.40) CYP19A1ALDH1A1KDM4EMAPK1GAA
SCHEMBL4750651 0.71 ALDH1A1 (0.43) ALDH1A1KDM4EMAPK1TSHRGAA
SCHEMBL10232910 0.69 KDM4E (0.41) ALDH1A1KDM4EMAPK1GRM2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008123755-A1 A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA SK CHEMICALS CO., LTD. (KR) 2008-10-16 WO claimed
WO-2006112666-A1 PYRIDINE DERIVATIVES, METHODS OF THEIR PREPARATIONS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME SK CHEMICALS CO., LTD. (KR) 2006-10-26 WO claimed
WO-2008123755-A1 A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA SK CHEMICALS CO., LTD. (KR) 2008-10-16 WO disclosed
WO-2006112666-A1 PYRIDINE DERIVATIVES, METHODS OF THEIR PREPARATIONS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME SK CHEMICALS CO., LTD. (KR) 2006-10-26 WO disclosed