Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749649 | 0.88 | PFKFB3 (0.43) | BRD4KDM4ENPC1RAB9AMAPT | |
| SCHEMBL4066864 | 0.85 | ALDH1A1 (0.39) | BRD4KDM4EKMT2AMEN1NPC1 | |
| SCHEMBL4073028 | 0.82 | APP (0.36) | KDM4EKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL4481191 | 0.79 | ALDH1A1 (0.46) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL4749025 | 0.78 | PIK3CA (0.39) | — | |
| SCHEMBL4064580 | 0.77 | SQOR (0.47) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL4071782 | 0.76 | HRH1 (0.49) | KDM4EKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL4063729 | 0.74 | PDE10A (0.38) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL4065502 | 0.73 | KDM4E (0.42) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL4063497 | 0.73 | KDM4E (0.44) | BRD4KDM4EKMT2AMEN1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123756-A1 | A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTON TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA | SK CHEMICALS CO., LTD. (KR) | 2008-10-16 | — | — | WO | claimed |