Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL4788727 | 0.99 | LTA4H (0.41) | LTA4HCHRNA7KDRSIGMAR1MC4R | |
| SCHEMBL4749778 | 0.88 | LTA4H (0.41) | LTA4HCHRNA7KDM4EALDH1A1POLB | |
| SCHEMBL4747133 | 0.87 | LTA4H (0.42) | LTA4HKDM4EALDH1A1POLBCYP2D6 | |
| SCHEMBL4788759 | 0.87 | LTA4H (0.40) | LTA4HCHRNA7KDM4EALDH1A1POLB | |
| SCHEMBL4747555 | 0.83 | FAAH (0.46) | LTA4HSIGMAR1KDM4EALDH1A1LMNA | |
| SCHEMBL4750958 | 0.80 | VEGFA (0.42) | KDM4EALDH1A1POLBCA2 | |
| SCHEMBL4788729 | 0.80 | CHRNA7 (0.39) | LTA4HCHRNA7KDRMC4RKDM4E | |
| SCHEMBL4838068 | 0.79 | KCNH2 (0.47) | ALDH1A1POLBHTR6LMNANCF1 | |
| SCHEMBL14157834 | 0.79 | KCNH2 (0.47) | ALDH1A1POLBHTR6LMNANCF1 | |
| SCHEMBL4834468 | 0.79 | KCNH2 (0.47) | ALDH1A1POLBHTR6LMNANCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |