Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9424254 | 0.89 | LMNA (0.74) | LMNAPOLBALDH1A1NPC1KMT2A | |
| SCHEMBL10816709 | 0.88 | LMNA (0.72) | LMNAPOLBALDH1A1NPC1KMT2A | |
| SCHEMBL5837384 | 0.87 | LMNA (0.71) | LMNAPOLBALDH1A1NPC1KMT2A | |
| SCHEMBL10996648 | 0.87 | LMNA (0.71) | LMNAPOLBALDH1A1NPC1KMT2A | |
| SCHEMBL6729463 | 0.85 | LMNA (0.64) | LMNAPOLBALDH1A1NPC1KMT2A | |
| Carbofuran SCHEMBL11213568 | 0.84 | LMNA (1.00) | LMNAPOLBALDH1A1NPC1KMT2A | |
| Carbofuran SCHEMBL21722098 | 0.84 | LMNA (1.00) | LMNAPOLBALDH1A1NPC1KMT2A | |
| Carbofuran SCHEMBL21656 | 0.84 | LMNA (1.00) | LMNAPOLBALDH1A1NPC1KMT2A | |
| SCHEMBL27964565 | 0.84 | LMNA (0.67) | LMNAPOLBALDH1A1NPC1KMT2A | |
| SCHEMBL11311097 | 0.84 | LMNA (0.67) | LMNAPOLBALDH1A1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110964023-B | Fused tetracyclic compounds and application thereof in medicines | 广东东阳光药业有限公司 | 2022-12-27 | — | — | CN | disclosed |
| US-11447498-B2 | Fused tetracyclic compounds and uses thereof in medicine | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2022-09-20 | — | — | US | disclosed |
| US-20220041614-A1 | FUSED TETRACYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2022-02-10 | — | — | US | disclosed |
| US-20220041614-A1 | FUSED TETRACYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2022-02-10 | — | — | US | disclosed |
| WO-2021143885-A1 | FUSED TETRACYCLIC COMPOUND AND APPLICATION THEREOF IN MEDICINE | 东莞市东阳光新药研发有限公司 | 2021-07-22 | — | — | WO | disclosed |
| CN-110964023-A | Fused tetracyclic compounds and application thereof in medicines | 广东东阳光药业有限公司 | 2020-04-07 | — | — | CN | disclosed |
| WO-2020063870-A1 | FUSED TETRACYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2020-04-02 | — | — | WO | disclosed |
| EP-2970172-B1 | BICYCLO [2.2.2]ACID GPR120 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2019-10-30 | — | — | EP | disclosed |
| EP-2970172-B1 | BICYCLO [2.2.2]ACID GPR120 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2019-10-30 | — | — | EP | disclosed |
| US-9598390-B2 | Bicyclo[2.2.2]acid GPR120 modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-21 | — | — | US | disclosed |
| US-20160039780-A1 | BICYCLO [2.2.2] ACID GPR120 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-02-11 | — | — | US | disclosed |
| EP-2970172-A1 | BICYCLO [2.2.2]ACID GPR120 MODULATORS | Bristol-Myers Squibb Company (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014159802-A1 | BICYCLO [2.2.2] ACID GPR120 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-10-02 | — | — | WO | disclosed |
| WO-2014159802-A1 | BICYCLO [2.2.2] ACID GPR120 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-10-02 | — | — | WO | disclosed |
| US-20110009351-A1 | SCREENING ASSAY TO IDENTIFY CORRECTORS OF PROTEIN TRAFFICKING DEFECTS | Traffick Therepeutics Inc. | 2011-01-13 | — | — | US | disclosed |
| WO-2008146064-A1 | NEW BENZOFURAN DERIVATIVES AS SELECTIVE 5HT7 RECEPTOR INHIBITORS AND PROCESS FOR THEIR PREPARATION | EGIS GYÓGYSZERGYÁR (HU) | 2008-12-04 | — | — | WO | disclosed |
| WO-2008146064-A1 | NEW BENZOFURAN DERIVATIVES AS SELECTIVE 5HT7 RECEPTOR INHIBITORS AND PROCESS FOR THEIR PREPARATION | EGIS GYÓGYSZERGYÁR (HU) | 2008-12-04 | — | — | WO | disclosed |
| US-20040186170-A1 | Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient | EGIS GYOGYSZERGYAR (HU) | 2004-09-23 | — | — | US | disclosed |
| US-4560682-A | INSECTICIDES, MITICIDES | MITSUBISHI CHEMICAL INDUSTRIES LTD. (JP) | 1985-12-24 | — | — | US | disclosed |
| EP-0139767-A1 | ORGANOPHOSPHORUS ESTER DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND INSECTICIDES CONTAINING THEM AS EFFECTIVE INGREDIENTS | MITSUBISHI KASEI CORPORATION (JP) | 1985-05-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447498-B2 | Fused tetracyclic compounds and uses thereof in medicine | SLC10A1, CYP4A11, CYP11B2 | LMNA 1375/4885POLB 2239/4885ALDH1A1 1555/4885 |
| US-20040186170-A1 | Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient | CYP2F1, CYP3A4, CYP2S1 | LMNA 2499/4885POLB 1666/4885ALDH1A1 81/4885 |
| US-20220041614-A1 | FUSED TETRACYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SLC10A1, CYP4A11, CYP11B2 | LMNA 1375/4885POLB 2239/4885ALDH1A1 1555/4885 |
| US-20160039780-A1 | BICYCLO [2.2.2] ACID GPR120 MODULATORS | GPR180, GPR88, GPBAR1 | LMNA 4470/4885POLB 4637/4885ALDH1A1 2403/4885 |
| US-20110009351-A1 | SCREENING ASSAY TO IDENTIFY CORRECTORS OF PROTEIN TRAFFICKING DEFECTS | CLINT1, SLC47A2, GOLT1B | LMNA 3618/4885POLB 4386/4885ALDH1A1 3256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.