Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7240564 | 0.81 | DRD2 (0.48) | KDM4EALDH1A1HSD17B10DRD2DRD3 | |
| SCHEMBL7240567 | 0.81 | DRD2 (0.48) | KDM4EALDH1A1HSD17B10DRD2DRD3 | |
| SCHEMBL6532743 | 0.81 | HTR3E (0.43) | KDM4EALDH1A1HSD17B10TMEM97SIGMAR1 | |
| SCHEMBL6819440 | 0.80 | ADRA1A (0.40) | KDM4EALDH1A1HSD17B10DRD2DRD3 | |
| SCHEMBL4213722 | 0.80 | ADRA1A (0.40) | KDM4EALDH1A1HSD17B10DRD2DRD3 | |
| SCHEMBL6823568 | 0.79 | DRD2 (0.43) | KDM4EALDH1A1HSD17B10DRD2DRD3 | |
| SCHEMBL6823565 | 0.79 | DRD2 (0.43) | KDM4EALDH1A1HSD17B10DRD2DRD3 | |
| SCHEMBL6820067 | 0.79 | ADRA1A (0.39) | KDM4EALDH1A1HSD17B10DRD2DRD3 | |
| SCHEMBL6820056 | 0.79 | ADRA1A (0.39) | KDM4EALDH1A1HSD17B10DRD2DRD3 | |
| SCHEMBL7246642 | 0.76 | ADRA1A (0.66) | DRD2DRD3ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130321-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR 5-HETEROCYCLYL-CHROMANE OR 8-HETEROCYCLYL-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |