Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753160 | 0.95 | ALDH1A1 (0.50) | ALDH1A1KDM4ECYP1A2CYP3A4GRM5 | |
| SCHEMBL4751028 | 0.90 | ALDH1A1 (0.45) | ALDH1A1KDM4ETSHRKMT2A | |
| SCHEMBL4750996 | 0.84 | ALDH1A1 (0.45) | ALDH1A1KDM4ECYP1A2SMN1; SMN2ALOX15 | |
| SCHEMBL4753147 | 0.82 | ALDH1A1 (0.45) | ALDH1A1KDM4EHTR7KMT2AL3MBTL1 | |
| SCHEMBL4750797 | 0.82 | GRM5 (0.41) | ALDH1A1KDM4ECYP1A2CYP3A4GRM5 | |
| SCHEMBL4750772 | 0.82 | ALDH1A1 (0.45) | ALDH1A1KDM4EUSP2KMT2AL3MBTL1 | |
| SCHEMBL4750792 | 0.78 | POLB (0.52) | ALDH1A1KDM4ECYP1A2TSHRKMT2A | |
| SCHEMBL4753111 | 0.78 | ALDH1A1 (0.42) | ALDH1A1KDM4EKMT2AL3MBTL1 | |
| SCHEMBL4751026 | 0.78 | MAPT (0.41) | ALDH1A1KDM4ECYP1A2TSHRSMN1; SMN2 | |
| SCHEMBL4753349 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KDM4EHTR7KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |