Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772429 | 0.91 | RORC (0.42) | DRD3DRD2RORCKAT6AHTR2A | |
| SCHEMBL4026119 | 0.83 | SLC18A3 (0.45) | RORCHTR2ASLC18A3MC4RMEN1 | |
| SCHEMBL4024282 | 0.83 | SLC18A3 (0.45) | RORCHTR2ASLC18A3MC4RMEN1 | |
| SCHEMBL4751331 | 0.81 | F2R (0.41) | RORCKAT6ASLC18A3MC4RMEN1 | |
| SCHEMBL4772340 | 0.80 | KMT2A (0.48) | DRD3DRD2DRD1DRD4DRD5 | |
| SCHEMBL4022920 | 0.77 | RORC (0.40) | DRD3DRD2RORCHTR2AOPRM1 | |
| SCHEMBL4020589 | 0.76 | RORC (0.43) | RORCHTR2ASLC18A3MEN1KMT2A | |
| SCHEMBL4776685 | 0.76 | RORC (0.43) | RORCHTR2ASLC18A3MEN1KMT2A | |
| SCHEMBL4026664 | 0.76 | RORC (0.41) | RORCOPRM1MEN1KMT2A | |
| SCHEMBL4022926 | 0.76 | RORC (0.41) | DRD3DRD2RORCHTR2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | claimed |
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |