Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751332 | 0.91 | DRD3 (0.46) | RORCSLC18A3DRD3DRD2MEN1 | |
| SCHEMBL4022920 | 0.86 | RORC (0.40) | RORCSLC18A3DRD3DRD2MEN1 | |
| SCHEMBL4026119 | 0.85 | SLC18A3 (0.45) | RORCSLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL4024282 | 0.85 | SLC18A3 (0.45) | RORCSLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL4026663 | 0.84 | RORC (0.41) | RORCSIGMAR1MEN1KMT2ANPC1 | |
| SCHEMBL4026664 | 0.84 | RORC (0.41) | RORCSIGMAR1MEN1KMT2ANPC1 | |
| SCHEMBL4751331 | 0.83 | F2R (0.41) | RORCSLC18A3MEN1KMT2AKAT6A | |
| SCHEMBL4772340 | 0.79 | KMT2A (0.48) | RORCDRD3DRD2MEN1KMT2A | |
| SCHEMBL4776685 | 0.78 | RORC (0.43) | RORCSLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL4020589 | 0.78 | RORC (0.43) | RORCSLC18A3SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | claimed |