SCHEMBL4751909

SCHEMBL4751909

COC1CN(C)Cc2sccc21

nearest known ligand 0.49

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
SLC6A2 P23975 14/20 0.37
SLC6A4 P31645 14/20 0.37
SLC6A3 Q01959 13/20 0.37
CYP2D6 P10635 1/20 0.35
PKM P14618 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3304815 0.83 DRD2 (0.40) NPC1RAB9A
SCHEMBL4751245 0.83 DRD2 (0.40) NPC1RAB9A
SCHEMBL11610711 0.80 PKM (0.50) NPC1RAB9ASLC6A2SLC6A4SLC6A3
SCHEMBL2841032 0.79 SLC6A2 (0.45) NPC1RAB9ASLC6A2SLC6A4SLC6A3
SCHEMBL11610914 0.76 NPC1 (0.44) NPC1RAB9ASLC6A2SLC6A4SLC6A3
SCHEMBL2835846 0.75 NPC1 (0.55) NPC1RAB9ASLC6A2SLC6A4SLC6A3
SCHEMBL2843946 0.74 NPC1 (0.42) NPC1RAB9ASLC6A2SLC6A4SLC6A3
SCHEMBL2840332 0.73 SLC6A2 (0.40) NPC1RAB9ASLC6A2SLC6A4SLC6A3
SCHEMBL2840634 0.73 NPC1 (0.39) NPC1RAB9ASLC6A2SLC6A4SLC6A3
SCHEMBL4752668 0.73 NPC1 (0.32) NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008135526-A1 CARBOXYLIC ACID AMIDES AS FACTOR XA INHIBITORS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-11-13 WO disclosed