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SCHEMBL4751952

SCHEMBL4751952

CC(C)C(NC(=O)OC(C)(C)C)C(=O)CC(=O)O

nearest known ligand 0.59

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ CTSK P43235 8/20 0.59
▸ CTSS P25774 4/20 0.59
▸ CA2 P00918 2/20 0.51
▸ CA1 P00915 1/20 0.51
▸ CA7 P43166 1/20 0.51
▸ CTSL P07711 2/20 0.47
▸ CTSB P07858 2/20 0.47
▸ CYP2D6 P10635 1/20 0.46
▸ PREP P48147 1/20 0.45
▸ TRPA1 O75762 2/20 0.44
▸ PSENEN Q9NZ42 1/20 0.40
▸ KLK5 Q9Y337 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3048922 1.00 CTSK (0.59) CTSKCTSSCA2CA1CA7
SCHEMBL28681860 1.00 CTSK (0.59) CTSKCTSSCA2CA1CA7
SCHEMBL17268414 0.86 CTSK (0.55) CTSKCTSSCA2CA1CA7
SCHEMBL17268444 0.86 CTSK (0.55) CTSKCTSSCA2CA1CA7
SCHEMBL4958751 0.85 CTSK (0.62) CTSKCTSSCA2CA1CA7
SCHEMBL10727467 0.85 CTSK (0.62) CTSKCTSSCA2CA1CA7
SCHEMBL10722482 0.85 CTSK (0.62) CTSKCTSSCA2CA1CA7
SCHEMBL20504152 0.85 CTSK (0.54) CTSKCTSSCA2CA1CA7
SCHEMBL2494959 0.85 CTSK (0.54) CTSKCTSSCA2CA1CA7
SCHEMBL14389814 0.84 CTSK (0.56) CTSKCTSSCA2CA1CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11535614-B2 Dihydropyrrolopyridine inhibitors of ROR-gamma VITAE PHARMACEUTICALS, LLC (US) 2022-12-27 — — US disclosed
CN-108463458-B Modulators of ROR-gamma 生命医药有限责任公司 2022-02-01 — — CN disclosed
US-20210238174-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA VITAE PHARMACEUTICALS, LLC 2021-08-05 — — US disclosed
US-11001583-B2 Dihydropyrrolopyridine inhibitors of ROR-gamma VITAE PHARMACEUTICALS, LLC (US) 2021-05-11 — — US disclosed
US-20200339566-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA VITAE PHARMACEUTICALS, INC. 2020-10-29 — — US disclosed
US-10807980-B2 Dihydropyrrolopyridine inhibitors of ROR-gamma VITAE PHARMACEUTICALS, LLC (US) 2020-10-20 — — US disclosed
US-20200172535-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA VITAE PHARMACEUTICALS, LLC 2020-06-04 — — US disclosed
US-20200079767-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA VITAE PHARMACEUTICALS, LLC 2020-03-12 — — US disclosed
EP-3207043-B3 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA VITAE PHARMACEUTICALS LLC (US) 2019-10-02 — — EP disclosed
US-10399976-B2 Dihydropyrrolopyridine inhibitors of ROR-gamma VITAE PHARMACEUTICALS, LLC (US) 2019-09-03 — — US disclosed
US-20180222902-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA VITAE PHARMACEUTICALS, LLC 2018-08-09 — — US disclosed
US-9796710-B2 Dihydropyrrolopyridine inhibitors of ROR-gamma VITAE PHARMACEUTICALS, INC. (US) 2017-10-24 — — US disclosed
US-20170260180-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA VITAE PHARMACEUTICALS, LLC 2017-09-14 — — US disclosed
US-9663515-B2 Dihydropyrrolopyridine inhibitors of ROR-gamma VITAE PHARMACEUTICALS, INC. (US) 2017-05-30 — — US disclosed
US-9624217-B2 Dihydropyrrolopyridine inhibitors of ROR-gamma VITAE PHARMACEUTICALS, INC. (US) 2017-04-18 — — US disclosed
US-20170081327-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA VITAE PHARMACEUTICALS, LLC 2017-03-23 — — US disclosed
US-9481674-B1 Dihydropyrrolopyridine inhibitors of ROR-gamma VITAE PHARMACEUTICALS, INC. (US) 2016-11-01 — — US disclosed
US-20160200724-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA VITAE PHARMACEUTICALS, LLC 2016-07-14 — — US disclosed
US-20160122345-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA VITAE PHARMACEUTICALS, LLC 2016-05-05 — — US disclosed
WO-2008132162-A1 3- (SULPHONYLAMINO) -PHENYL-2 -HYDROXY-ETHYLAMINO DERIVATIVES USEFUL AS BETA-AGONISTS, PROCESSES FOR PREPARING THEM AND THEIR USE AS MEDICAMENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-11-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11001583-B2 Dihydropyrrolopyridine inhibitors of ROR-gamma RORC, RORB, RORA CTSK 4102/4885CTSS 4720/4885CA2 1302/4885
US-20200172535-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA RORC, RORB, RORA CTSK 4102/4885CTSS 4720/4885CA2 1302/4885
US-10399976-B2 Dihydropyrrolopyridine inhibitors of ROR-gamma RORC, RORB, RORA CTSK 4223/4885CTSS 4754/4885CA2 1037/4885
US-20210238174-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA RORC, RORB, RORA CTSK 4102/4885CTSS 4720/4885CA2 1302/4885
US-20180222902-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA RORC, RORB, RORA CTSK 4102/4885CTSS 4720/4885CA2 1302/4885
US-20170260180-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA RORC, RORB, RORA CTSK 4102/4885CTSS 4720/4885CA2 1302/4885
US-20160122345-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA RORC, RORB, RORA CTSK 4102/4885CTSS 4720/4885CA2 1302/4885
US-20170081327-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA RORC, RORB, RORA CTSK 4223/4885CTSS 4754/4885CA2 1037/4885
US-10807980-B2 Dihydropyrrolopyridine inhibitors of ROR-gamma RORC, RORB, RORA CTSK 4102/4885CTSS 4720/4885CA2 1302/4885
US-20200079767-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA RORC, RORB, RORA CTSK 4102/4885CTSS 4720/4885CA2 1302/4885
US-20160200724-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA RORC, RORB, RORA CTSK 4102/4885CTSS 4720/4885CA2 1302/4885
US-20200339566-A1 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA RORC, RORB, RORA CTSK 4102/4885CTSS 4720/4885CA2 1302/4885
US-11535614-B2 Dihydropyrrolopyridine inhibitors of ROR-gamma RORC, RORB, RORA CTSK 4102/4885CTSS 4720/4885CA2 1302/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.