SCHEMBL4749303

SCHEMBL4749303

Cc1c(F)cccc1[C@@H]1[C@@H](C(=O)c2cccc(O)c2)CN(C[C@H](N(C)C)C(C)(C)O)C[C@H]1C(=O)c1cccc(O)c1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDM2B Q8NHM5 2/20 0.31
KIF11 P52732 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4749092 1.00 KDM2B (0.31) KDM2BKIF11
SCHEMBL4749288 1.00 KDM2B (0.31) KDM2BKIF11
SCHEMBL4749084 1.00 KDM2B (0.31) KDM2BKIF11
SCHEMBL4749085 0.91 HTR1A (0.31) KDM2B
SCHEMBL4749073 0.91 HTR1A (0.31) KDM2B
SCHEMBL4787486 0.91 HSD17B1 (0.32) KDM2B
SCHEMBL4752898 0.89
SCHEMBL4021957 0.88 KDM2B (0.32) KDM2B
SCHEMBL4025503 0.87 KIF11 (0.34) KDM2BKIF11
SCHEMBL4020419 0.86 KDM2B (0.32) KDM2BKIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008140810-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS CYTOKINETICS, INCORPORATED (US) 2008-11-20 WO claimed
WO-2008140810-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS CYTOKINETICS, INCORPORATED (US) 2008-11-20 WO disclosed