Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 6/20 | 0.47 |
| ▸ | PROKR1 | Q8TCW9 | 6/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 3/20 | 0.45 |
| ▸ | CCR3 | P51677 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8096418 | 0.80 | FPR2 (0.46) | FPR2PROKR1MMP12MMP13HRH1 | |
| SCHEMBL4757515 | 0.77 | MEN1 (0.51) | MAPT | |
| SCHEMBL4752287 | 0.76 | FPR2 (0.48) | FPR2PROKR1MMP12MMP13HRH1 | |
| SCHEMBL8286689 | 0.76 | ACLY (0.45) | FPR2PROKR1MMP12MMP13HRH1 | |
| SCHEMBL5020187 | 0.76 | FPR2 (0.49) | FPR2PROKR1MMP12MMP13HRH1 | |
| SCHEMBL4752293 | 0.75 | FPR2 (0.57) | FPR2PROKR1MMP12MMP13HRH1 | |
| SCHEMBL4673429 | 0.73 | FPR2 (0.50) | FPR2PROKR1MMP12MMP13HRH1 | |
| SCHEMBL4673324 | 0.70 | MMP1 (0.59) | FPR2PROKR1MMP12MMP13HRH1 | |
| SCHEMBL4673329 | 0.70 | MMP1 (0.59) | FPR2PROKR1MMP12MMP13HRH1 | |
| SCHEMBL4673327 | 0.70 | MMP1 (0.59) | FPR2PROKR1MMP12MMP13HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147764-A1 | MMP INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA, INC. (US) | 2008-12-04 | — | — | WO | disclosed |