Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 10/20 | 0.48 |
| ▸ | PROKR1 | Q8TCW9 | 10/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | CCR3 | P51677 | 3/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753890 | 0.89 | FPR2 (0.51) | FPR2PROKR1HRH1CCR3KCNH2 | |
| SCHEMBL4788541 | 0.88 | FPR2 (0.48) | FPR2PROKR1MMP12MMP13MAPT | |
| SCHEMBL4789823 | 0.81 | HSD11B1 (0.47) | MAPT | |
| SCHEMBL5020187 | 0.81 | FPR2 (0.49) | FPR2PROKR1MMP12MMP13MAPT | |
| SCHEMBL4753032 | 0.76 | FPR2 (0.47) | FPR2PROKR1MMP12MMP13MAPT | |
| SCHEMBL4789296 | 0.76 | GPR119 (0.43) | SMN1; SMN2 | |
| SCHEMBL8096418 | 0.74 | FPR2 (0.46) | FPR2PROKR1MMP12MMP13MAPT | |
| SCHEMBL5020189 | 0.71 | FPR2 (0.52) | FPR2PROKR1HRH1CCR3KCNH2 | |
| SCHEMBL4752293 | 0.70 | FPR2 (0.57) | FPR2PROKR1MMP12MMP13MAPT | |
| SCHEMBL8286689 | 0.69 | ACLY (0.45) | FPR2PROKR1MMP12MMP13MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147764-A1 | MMP INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA, INC. (US) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147764-A1 | MMP INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA, INC. (US) | 2008-12-04 | — | — | WO | disclosed |