Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5093036 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNAGAATSHR | |
| SCHEMBL5128261 | 0.76 | EPHX2 (0.47) | ALDH1A1MAPTKDM4E | |
| SCHEMBL3926267 | 0.75 | ALDH1A1 (0.47) | ALDH1A1MAPTPKMKMT2AMEN1 | |
| SCHEMBL5666046 | 0.75 | ALDH1A1 (0.44) | ALDH1A1MAPTPKMPOLBGAA | |
| SCHEMBL3917745 | 0.73 | ALDH1A1 (0.43) | ALDH1A1MAPTPKMKMT2AMEN1 | |
| SCHEMBL5088905 | 0.72 | EPHX2 (0.52) | ALDH1A1TSHRKMT2AL3MBTL1MEN1 | |
| SCHEMBL13726504 | 0.72 | CRHBP (0.69) | ALDH1A1MAPTPKMLMNAPOLB | |
| SCHEMBL7131206 | 0.71 | KDM4E (0.78) | ALDH1A1MAPTLMNAPOLBGAA | |
| SCHEMBL19991949 | 0.71 | LMNA (0.73) | ALDH1A1LMNAGAATSHRL3MBTL1 | |
| SCHEMBL13726176 | 0.71 | LMNA (0.75) | ALDH1A1MAPTPKMLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |