Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MC4R | P32245 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20149549 | 0.84 | CRHBP (0.68) | LMNAPOLBKMT2AKDM4EALDH1A1 | |
| SCHEMBL4750798 | 0.80 | KDM4E (0.56) | LMNAPOLBKMT2AKDM4EALDH1A1 | |
| SCHEMBL10598309 | 0.75 | CYP1A2 (0.50) | KMT2AALDH1A1HSD17B10 | |
| SCHEMBL29417917 | 0.75 | CYP1A2 (0.50) | KMT2AALDH1A1HSD17B10 | |
| SCHEMBL15800713 | 0.74 | ACHE (0.62) | SIGMAR1LMNAKMT2AKDM4EALDH1A1 | |
| SCHEMBL1415730 | 0.74 | SIGMAR1 (1.00) | SIGMAR1LMNAPOLBKMT2AMC4R | |
| SCHEMBL1041303 | 0.74 | SIGMAR1 (1.00) | SIGMAR1LMNAPOLBKMT2AMC4R | |
| SCHEMBL2489199 | 0.74 | SIGMAR1 (1.00) | SIGMAR1LMNAPOLBKMT2AMC4R | |
| SCHEMBL8188324 | 0.74 | SIGMAR1 (1.00) | SIGMAR1LMNAPOLBKMT2AMC4R | |
| SCHEMBL576868 | 0.74 | SIGMAR1 (1.00) | SIGMAR1LMNAPOLBKMT2AMC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |