Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753312 | 0.80 | SIGMAR1 (0.55) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL108678 | 0.78 | KDM4E (0.70) | KDM4EMEN1KMT2AHSD17B10USP2 | |
| SCHEMBL2316901 | 0.77 | CYP2D6 (0.82) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL8916005 | 0.75 | HTT (0.67) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2056152 | 0.74 | KDM4E (0.62) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13062752 | 0.74 | ALDH1A1 (0.64) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20149549 | 0.74 | CRHBP (0.68) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL8229803 | 0.73 | NCF1 (0.71) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL13007677 | 0.73 | KDM4E (0.58) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27683423 | 0.73 | KDM4E (0.60) | KDM4EALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |