Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 5/20 | 0.65 |
| ▸ | DRD4 | P21917 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13681864 | 0.82 | DRD2 (0.49) | HTR7DRD4DRD2DRD3KMT2A | |
| SCHEMBL12991804 | 0.82 | ADORA1 (0.53) | HTR7DRD4DRD2DRD3KMT2A | |
| SCHEMBL28230641 | 0.82 | HTR7 (0.80) | HTR7DRD4DRD2DRD3 | |
| SCHEMBL13219071 | 0.80 | ALDH1A1 (0.74) | HTR7DRD4DRD2DRD3KMT2A | |
| SCHEMBL27617560 | 0.80 | KDM4E (0.60) | DRD2KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL8111511 | 0.79 | HTT (0.77) | HTR7DRD4DRD2DRD3KMT2A | |
| SCHEMBL15938148 | 0.79 | HTR7 (1.00) | HTR7DRD4DRD2DRD3KMT2A | |
| SCHEMBL29764254 | 0.79 | HTR7 (1.00) | HTR7DRD4DRD2DRD3KMT2A | |
| SCHEMBL13149646 | 0.78 | HTR7 (0.55) | HTR7ALDH1A1TSHRMAPTKDM4E | |
| SCHEMBL4254056 | 0.78 | DRD4 (0.56) | DRD4DRD2DRD3KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |