Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.40 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.40 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.40 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.40 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.40 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | CACNA1E | Q15878 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4817673 | 0.71 | SMN1; SMN2 (0.56) | ALOX5PTGESTDP2NSD2PAX8 | |
| SCHEMBL27999385 | 0.70 | L3MBTL1 (0.51) | ALDH1A1SMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL16851058 | 0.68 | SMN1; SMN2 (0.63) | ALOX5PTGESCACNB4CACNA1ACACNA1G | |
| SCHEMBL4862480 | 0.68 | IGF1R (0.39) | ALDH1A1SMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL4202642 | 0.67 | IGF1R (0.53) | ALOX5PTGESERN1ALDH1A1LMNA | |
| SCHEMBL16620774 | 0.67 | CHRM2 (0.39) | ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL29960126 | 0.67 | ADORA1 (0.47) | ALDH1A1MAPTLMNA | |
| SCHEMBL688430 | 0.66 | PRKCZ (0.63) | ALDH1A1MAPTLMNAPTPN1HPGD | |
| SCHEMBL4816787 | 0.65 | SMN1; SMN2 (0.53) | ALOX5PTGESTDP2NSD2PAX8 | |
| SCHEMBL23174287 | 0.65 | L3MBTL1 (0.42) | TSHRLMNAATMIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008145398-A1 | 4-ARYLPYRROLE SUBSTITUTED 2-INDOLINE DERIVATIVES ACTIVE AS PROTEIN KINASE INHIBITORS | PFIZER ITALIA S.R.L. (IT) | 2008-12-04 | — | — | WO | disclosed |