Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4750915 | 0.88 | SMN1; SMN2 (0.38) | IGF1RSMN1; SMN2ADORA1ALDH1A1MAPT | |
| SCHEMBL4753369 | 0.73 | L3MBTL1 (0.37) | IGF1RSMN1; SMN2ADORA1MAPTKMT2A | |
| SCHEMBL4754352 | 0.70 | SMN1; SMN2 (0.50) | IGF1RSMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL4753365 | 0.68 | ALOX5 (0.43) | IGF1RSMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL23040402 | 0.67 | ADORA1 (0.40) | SMN1; SMN2ADORA1ALDH1A1MAPTLMNA | |
| SCHEMBL2813774 | 0.67 | NOD2 (0.40) | ADORA1ALDH1A1KMT2AHPGD | |
| SCHEMBL14398401 | 0.67 | KMT2A (0.51) | IGF1RADORA1ALDH1A1KMT2AUSP2 | |
| SCHEMBL25620998 | 0.67 | CA12 (0.49) | SMN1; SMN2ALDH1A1MAPTLMNANPSR1 | |
| SCHEMBL8232783 | 0.65 | ADORA1 (0.43) | SMN1; SMN2ADORA1ALDH1A1LMNANPSR1 | |
| SCHEMBL556981 | 0.65 | ADORA1 (0.47) | SMN1; SMN2ADORA1ALDH1A1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008145398-A1 | 4-ARYLPYRROLE SUBSTITUTED 2-INDOLINE DERIVATIVES ACTIVE AS PROTEIN KINASE INHIBITORS | PFIZER ITALIA S.R.L. (IT) | 2008-12-04 | — | — | WO | disclosed |