Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4862480 | 0.73 | IGF1R (0.39) | ADORA1MAPTSMN1; SMN2USP2IGF1R | |
| SCHEMBL2813827 | 0.72 | L3MBTL1 (0.42) | L3MBTL1ADORA1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL16079405 | 0.70 | ADORA1 (0.40) | ADORA1CA12CA1CA2CA7 | |
| SCHEMBL15308528 | 0.69 | ADORA1 (0.41) | ADORA1CA12CA1CA2CA7 | |
| SCHEMBL4830101 | 0.69 | CA12 (0.50) | CA12CA1CA2CA7CA9 | |
| SCHEMBL4752944 | 0.69 | SMN1; SMN2 (0.47) | ADORA1CA12CA1CA2CA7 | |
| SCHEMBL9080409 | 0.69 | TSHR (0.43) | L3MBTL1CA12CA1CA2CA7 | |
| SCHEMBL23040402 | 0.69 | ADORA1 (0.40) | ADORA1GPR119MAPTSMN1; SMN2TP53 | |
| SCHEMBL16048994 | 0.68 | ADORA1 (0.40) | ADORA1CA12CA1CA2CA7 | |
| SCHEMBL17643748 | 0.68 | CRHBP (0.34) | ADORA1CRHBPCRHR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008145398-A1 | 4-ARYLPYRROLE SUBSTITUTED 2-INDOLINE DERIVATIVES ACTIVE AS PROTEIN KINASE INHIBITORS | PFIZER ITALIA S.R.L. (IT) | 2008-12-04 | — | — | WO | disclosed |