Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 8/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4754003 | 0.89 | SLC6A4 (0.44) | HTTTSHRMAPK1MEN1MAPT | |
| SCHEMBL4756964 | 0.89 | REN (0.41) | HTTTSHRMAPK1MEN1MAPT | |
| SCHEMBL4754375 | 0.89 | HTT (0.43) | HTTTSHRMAPK1MEN1MAPT | |
| SCHEMBL4757031 | 0.88 | EPHX2 (0.41) | HTTTSHRMAPK1MEN1MAPT | |
| SCHEMBL4753686 | 0.81 | PYGL (0.37) | HTTTSHRMAPK1MEN1MAPT | |
| SCHEMBL4755350 | 0.78 | SLC6A4 (0.40) | HTTTSHRMAPK1MEN1MAPT | |
| SCHEMBL498922 | 0.77 | SLC6A4 (0.52) | HTTTSHRMAPK1MEN1MAPT | |
| SCHEMBL499203 | 0.77 | SLC6A4 (0.52) | HTTTSHRMAPK1MEN1MAPT | |
| SCHEMBL499080 | 0.73 | REN (0.48) | HTTTSHRMAPK1MEN1MAPT | |
| SCHEMBL499694 | 0.73 | REN (0.48) | HTTTSHRMAPK1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156816-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |