Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755995 | 0.91 | PYGL (0.38) | PYGLHPGDLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4753692 | 0.81 | HTT (0.42) | HPGDLMNASMN1; SMN2MAPTTP53 | |
| SCHEMBL499262 | 0.77 | NOS2 (0.41) | PYGLL3MBTL1HPGDLMNAALDH1A1 | |
| SCHEMBL8080309 | 0.77 | NOS2 (0.41) | PYGLL3MBTL1HPGDLMNAALDH1A1 | |
| SCHEMBL4754003 | 0.72 | SLC6A4 (0.44) | HPGDLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4756964 | 0.72 | REN (0.41) | LMNASMN1; SMN2MAPTRENTSHR | |
| SCHEMBL4754375 | 0.72 | HTT (0.43) | HPGDLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4757031 | 0.71 | EPHX2 (0.41) | LMNASMN1; SMN2MAPTRENTSHR | |
| SCHEMBL15107593 | 0.71 | L3MBTL1 (0.38) | PYGLL3MBTL1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL2027998 | 0.68 | MRGPRX4 (0.40) | LMNAALDH1A1SMN1; SMN2MAPTREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156816-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |