Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 8/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755350 | 0.90 | SLC6A4 (0.40) | HTTMAPTTSHRMAPK1MEN1 | |
| SCHEMBL4753692 | 0.89 | HTT (0.42) | HTTMAPTTSHRMAPK1MEN1 | |
| SCHEMBL4756964 | 0.87 | REN (0.41) | HTTMAPTTSHRMAPK1MEN1 | |
| SCHEMBL4757031 | 0.86 | EPHX2 (0.41) | HTTMAPTTSHRMAPK1MEN1 | |
| SCHEMBL4754003 | 0.78 | SLC6A4 (0.44) | HTTMAPTTSHRMAPK1MEN1 | |
| SCHEMBL499635 | 0.76 | REN (0.46) | HTTMAPTTSHRMAPK1MEN1 | |
| SCHEMBL27752438 | 0.74 | WDR5 (0.50) | MAPTMEN1KMT2ARAB9AHPGD | |
| SCHEMBL498922 | 0.73 | SLC6A4 (0.52) | HTTMAPTTSHRMAPK1MEN1 | |
| SCHEMBL499203 | 0.73 | SLC6A4 (0.52) | HTTMAPTTSHRMAPK1MEN1 | |
| SCHEMBL14252613 | 0.72 | ADRB2 (0.43) | MAPK1HPGDSLC6A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156816-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |