Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4754060 | 0.88 | SLC6A7 (0.67) | ALDH1A1KDM4EHSD17B10HPGDSLC6A7 | |
| SCHEMBL3817981 | 0.83 | ALDH1A1 (0.64) | ALDH1A1KDM4EHSD17B10HPGDMAPK1 | |
| SCHEMBL8154101 | 0.81 | SLC6A7 (1.00) | ALDH1A1KDM4EHPGDMAPK1SLC6A7 | |
| SCHEMBL4698854 | 0.81 | SLC6A7 (0.70) | ALDH1A1KDM4EHSD17B10HPGDMAPK1 | |
| SCHEMBL13601160 | 0.81 | ALDH1A1 (0.79) | ALDH1A1KDM4EHPGDMAPK1SLC6A7 | |
| SCHEMBL3578857 | 0.81 | SLC6A7 (0.78) | ALDH1A1KDM4EHSD17B10HPGDMAPK1 | |
| SCHEMBL3579131 | 0.78 | SLC6A7 (0.83) | ALDH1A1KDM4EHSD17B10HPGDMAPK1 | |
| SCHEMBL3821678 | 0.74 | ALDH1A1 (0.65) | ALDH1A1KDM4EHSD17B10HPGDSLC6A7 | |
| SCHEMBL4426141 | 0.74 | KMT2A (1.00) | ALDH1A1KDM4EHSD17B10HPGDLMNA | |
| SCHEMBL1459007 | 0.74 | ALDH1A1 (0.68) | ALDH1A1KDM4EHSD17B10HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089018-A2 | METHODS OF TREATING COGNITIVE IMPAIRMENT AND DEMENTIA | Lexicon Pharmaceuticals, Inc. (US) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008067121-A2 | METHODS OF TREATING COGNITIVE IMPAIRMENT AND DEMENTIA | LEXICON PHARMACEUTICALS, INC. (US) | 2008-06-05 | — | — | WO | disclosed |
| EP-1893212-A2 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006124748-A2 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | LEXICON GENETICS INCORPORATED (US) | 2006-11-23 | — | — | WO | disclosed |