Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 12/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3817716 | 0.84 | SLC6A7 (0.63) | SLC6A7ALDH1A1TSHRKDM4EL3MBTL1 | |
| SCHEMBL5935798 | 0.80 | SLC6A7 (0.59) | SLC6A7ALDH1A1TSHRKDM4EL3MBTL1 | |
| SCHEMBL4754060 | 0.80 | SLC6A7 (0.67) | SLC6A7ALDH1A1TSHRKDM4EL3MBTL1 | |
| SCHEMBL3572601 | 0.79 | SLC6A7 (1.00) | SLC6A7ALDH1A1TSHRKDM4EL3MBTL1 | |
| SCHEMBL3578419 | 0.75 | SLC6A7 (0.77) | SLC6A7ALDH1A1TSHRKDM4EL3MBTL1 | |
| SCHEMBL3580304 | 0.74 | SLC6A7 (0.70) | SLC6A7ALDH1A1TSHRKDM4EL3MBTL1 | |
| SCHEMBL28768954 | 0.73 | GSTA1 (0.45) | — | |
| SCHEMBL3817981 | 0.73 | ALDH1A1 (0.64) | SLC6A7ALDH1A1TSHRKDM4EL3MBTL1 | |
| SCHEMBL5823604 | 0.73 | KDM4E (0.60) | SLC6A7ALDH1A1TSHRKDM4EL3MBTL1 | |
| SCHEMBL3579156 | 0.73 | SLC6A7 (0.75) | SLC6A7ALDH1A1TSHRKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893212-A2 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006124748-A2 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | LEXICON GENETICS INCORPORATED (US) | 2006-11-23 | — | — | WO | claimed |
| EP-2089018-A2 | METHODS OF TREATING COGNITIVE IMPAIRMENT AND DEMENTIA | Lexicon Pharmaceuticals, Inc. (US) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008067121-A2 | METHODS OF TREATING COGNITIVE IMPAIRMENT AND DEMENTIA | LEXICON PHARMACEUTICALS, INC. (US) | 2008-06-05 | — | — | WO | disclosed |
| WO-2006124897-A2 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITION | LEXICON GENETICS INCORPORATED (US) | 2006-11-23 | — | — | WO | disclosed |