Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | DHFR | P00374 | 4/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.39 |
| ▸ | FPGS | Q05932 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13984109 | 0.83 | QTRT1 (0.52) | TYMSKMT2AMEN1KDM4EHSD17B10 | |
| SCHEMBL4753842 | 0.82 | TYMS (0.44) | TYMSKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL4753487 | 0.81 | TNKS (0.51) | TYMSKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL4755224 | 0.81 | DHFR (0.52) | KMT2AMEN1DHFR | |
| SCHEMBL4753204 | 0.79 | TYMS (0.50) | TYMSKMT2AMEN1KDM4EHSD17B10 | |
| SCHEMBL4756543 | 0.75 | TYMS (0.45) | TYMSKMT2AMEN1KDM4EHSD17B10 | |
| SCHEMBL13983986 | 0.74 | GAA (0.52) | KMT2AKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL4753152 | 0.74 | QTRT1 (0.56) | TYMSKDM4EDHFRMAPK14QTRT1 | |
| SCHEMBL2216111 | 0.73 | TUBB1 (0.67) | KMT2AMEN1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL2117452 | 0.71 | KDM4E (0.54) | TYMSKMT2AMEN1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | claimed |
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | disclosed |