Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.40 |
| ▸ | KCNK10 | P57789 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755522 | 0.85 | KMT2A (0.46) | MAPTKDM4ELMNAPKMMAPK1 | |
| SCHEMBL4753250 | 0.82 | ALDH1A1 (0.56) | MAPTKMT2AALDH1A1 | |
| SCHEMBL4755362 | 0.81 | PRSS1 (0.40) | — | |
| SCHEMBL4755444 | 0.78 | ALDH1A1 (0.42) | MAPTALDH1A1 | |
| SCHEMBL4753332 | 0.76 | KMT2A (0.52) | MAPTKDM4EKMT2AALDH1A1 | |
| SCHEMBL4755431 | 0.76 | HTT (0.44) | — | |
| SCHEMBL4756506 | 0.75 | DHFR (0.50) | KMT2A | |
| SCHEMBL4753631 | 0.73 | KMT2A (0.43) | MAPTKDM4ELMNAPKMMAPK1 | |
| SCHEMBL13983985 | 0.73 | GAA (0.55) | MAPTKDM4ELMNAPKMMAPK1 | |
| SCHEMBL4755224 | 0.73 | DHFR (0.52) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | claimed |
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | disclosed |