Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4754963 | 0.81 | KDR (0.39) | KDRPDGFRBHSD17B10KDM4EALDH1A1 | |
| SCHEMBL10500542 | 0.71 | KDR (0.43) | KDRPDGFRBHSD17B10KDM4EALDH1A1 | |
| SCHEMBL3863859 | 0.69 | KDR (0.45) | KDRPDGFRBHSD17B10KDM4EALDH1A1 | |
| SCHEMBL18955834 | 0.65 | KDR (0.58) | KDRPDGFRBMEN1KMT2A | |
| SCHEMBL15069721 | 0.63 | KDR (0.64) | KDRPDGFRBKDM4EALDH1A1MEN1 | |
| SCHEMBL4755614 | 0.63 | MEN1 (0.35) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL4758106 | 0.61 | CISD2 (0.39) | HSD17B10KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL12894820 | 0.60 | KDR (0.35) | KDRPDGFRBALDH1A1MAPTHPGD | |
| SCHEMBL3084536 | 0.60 | ALDH1A1 (0.39) | KDRPDGFRBHSD17B10ALDH1A1MAPT | |
| SCHEMBL8188239 | 0.57 | KDM4E (0.40) | KDRPDGFRBHSD17B10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001214-A2 | THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE, ISOXAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE AND ISOTHIAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001214-A2 | THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE, ISOXAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE AND ISOTHIAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009002106-A2 | ANTI-CANCER COMPOSITION COMPRISING AQUATIC MICROBIAL EXTRACT | AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2008-12-31 | — | — | WO | disclosed |