Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 14/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757784 | 0.81 | CALCRL (0.53) | CALCRLSMN1; SMN2NOTUMMAPT | |
| SCHEMBL4756909 | 0.80 | RXRA (0.37) | CALCRLSMN1; SMN2NOTUM | |
| SCHEMBL4758257 | 0.79 | RXRA (0.43) | CALCRLSMN1; SMN2NOTUMALDH1A1MAPT | |
| SCHEMBL4757912 | 0.79 | RXRA (0.38) | CALCRLSMN1; SMN2NOTUMMAPT | |
| SCHEMBL4757918 | 0.74 | CALCRL (0.40) | CALCRLSMN1; SMN2NOTUMPIK3CDPIK3CA | |
| SCHEMBL4755677 | 0.74 | CALCRL (0.54) | CALCRLSMN1; SMN2MAPT | |
| SCHEMBL4758251 | 0.74 | CALCRL (0.46) | CALCRLSMN1; SMN2NOTUMALDH1A1MAPT | |
| SCHEMBL4757749 | 0.73 | CALCRL (0.38) | CALCRLSMN1; SMN2NOTUMALDH1A1MAPT | |
| SCHEMBL4757886 | 0.72 | NOTUM (0.48) | CALCRLSMN1; SMN2NOTUMALDH1A1MAPT | |
| Lithium SCHEMBL4757927 | 0.72 | CALCRL (0.40) | CALCRLSMN1; SMN2NOTUMPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009000819-A1 | 5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | WO | disclosed |