Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.37 |
| ▸ | RXRB | P28702 | 5/20 | 0.37 |
| ▸ | RXRG | P48443 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | CALCRL | Q16602 | 5/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.34 |
| ▸ | KAT5 | Q92993 | 2/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.34 |
| ▸ | KAT7 | O95251 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757912 | 0.99 | RXRA (0.38) | RXRARXRBRXRGSMN1; SMN2ATR | |
| SCHEMBL4755690 | 0.80 | CALCRL (0.40) | SMN1; SMN2CALCRLNOTUM | |
| SCHEMBL4758257 | 0.79 | RXRA (0.43) | RXRARXRBRXRGSMN1; SMN2CALCRL | |
| SCHEMBL4757784 | 0.77 | CALCRL (0.53) | SMN1; SMN2ATRCALCRLKAT5KAT7 | |
| SCHEMBL4755677 | 0.74 | CALCRL (0.54) | SMN1; SMN2CALCRL | |
| SCHEMBL4758251 | 0.74 | CALCRL (0.46) | RXRARXRBRXRGSMN1; SMN2CALCRL | |
| SCHEMBL4757749 | 0.73 | CALCRL (0.38) | RXRARXRBRXRGSMN1; SMN2ATR | |
| SCHEMBL4757886 | 0.72 | NOTUM (0.48) | RXRARXRBRXRGSMN1; SMN2CALCRL | |
| SCHEMBL4757918 | 0.72 | CALCRL (0.40) | SMN1; SMN2CALCRLNOTUM | |
| SCHEMBL4758259 | 0.71 | CALCRL (0.69) | CALCRL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009000819-A1 | 5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | WO | disclosed |