Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.60 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RBP4 | P02753 | 2/20 | 0.47 |
| ▸ | PPIA | P62937 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1819622 | 0.86 | LMNA (0.62) | DPP4DPP7KCNH2LMNAGAA | |
| SCHEMBL30681561 | 0.86 | LMNA (0.62) | DPP4DPP7KCNH2LMNAGAA | |
| SCHEMBL1222596 | 0.83 | POLB (0.56) | DPP4DPP7KCNH2LMNAALDH1A1 | |
| SCHEMBL6930440 | 0.82 | LMNA (0.63) | LMNAGAAKMT2AMEN1ALDH1A1 | |
| SCHEMBL23573376 | 0.82 | CYP2C9 (0.64) | DPP4DPP7CYP2C9CYP2C19HTR2B | |
| SCHEMBL4955801 | 0.80 | POLB (0.52) | GAAKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL5183787 | 0.80 | MGLL (0.60) | CYP2C9CYP2C19HTR2BMAPK14ALDH1A1 | |
| SCHEMBL5184222 | 0.78 | SCD (0.53) | CYP2C9CYP2C19HTR2BMAPK14LMNA | |
| SCHEMBL1812335 | 0.77 | SCD (0.57) | — | |
| SCHEMBL995119 | 0.77 | POLB (0.66) | KMT2AMEN1ALDH1A1POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008157844-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-12-24 | — | — | WO | disclosed |