Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2060435 | 0.85 | CRBN (0.56) | KMT2AMEN1ALDH1A1SMN1; SMN2NPC1 | |
| Water SCHEMBL28110279 | 0.83 | CRBN (0.55) | KMT2AMEN1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4960760 | 0.82 | NPC1 (0.53) | POLBKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL22720116 | 0.82 | ALDH1A1 (0.66) | KMT2AMEN1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL13161898 | 0.82 | ALDH1A1 (0.61) | KMT2AMEN1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3959130 | 0.81 | SIGMAR1 (0.73) | POLBKMT2AMEN1SIGMAR1L3MBTL1 | |
| SCHEMBL8477120 | 0.81 | CNR1 (0.52) | POLBKMT2AMEN1ALDH1A1SIGMAR1 | |
| SCHEMBL4960694 | 0.81 | POLB (0.58) | POLBKMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL2154833 | 0.80 | ALDH1A1 (0.69) | POLBKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29229446 | 0.80 | ALDH1A1 (0.69) | POLBKMT2AMEN1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008094909-A2 | QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-07 | — | — | WO | disclosed |