Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753686 | 0.91 | PYGL (0.37) | PYGLKDM4ECYP1A2CYP2C19TDP1 | |
| SCHEMBL4754003 | 0.81 | SLC6A4 (0.44) | CYP1A2CYP2C19MEN1HTTKMT2A | |
| SCHEMBL4755992 | 0.76 | NOS2 (0.43) | PYGLKDM4ENPSR1CYP1A2CYP2D6 | |
| SCHEMBL4755350 | 0.72 | SLC6A4 (0.40) | KDM4ECYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL4753692 | 0.71 | HTT (0.42) | NPSR1CYP1A2CYP2C19MEN1HTT | |
| SCHEMBL8080309 | 0.68 | NOS2 (0.41) | PYGLKDM4ECYP1A2CYP2C19MEN1 | |
| SCHEMBL499262 | 0.68 | NOS2 (0.41) | PYGLKDM4ECYP1A2CYP2C19MEN1 | |
| SCHEMBL21595688 | 0.67 | KDM4E (0.62) | KDM4ENPSR1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL25212618 | 0.65 | KDM4E (0.69) | KDM4ENPSR1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL25244653 | 0.65 | KDM4E (0.69) | KDM4ENPSR1CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156816-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |