Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL475619 | 0.81 | ADRB1 (0.46) | ADRB1HTR1AHTR1DHTR1BHTR3E | |
| SCHEMBL475403 | 0.80 | ADRB1 (0.45) | ADRB1HTR1AHTR1DHTR1BHTR3E | |
| Hydrochloric Acid SCHEMBL1748218 | 0.80 | ADRB1 (0.45) | ADRB1HTR1AHTR1DHTR1BHTR3E | |
| Hydrochloric Acid SCHEMBL1748341 | 0.79 | ADRB1 (0.44) | ADRB1HTR1AHTR1DHTR1BHTR3E | |
| SCHEMBL3919507 | 0.79 | HTR6 (0.48) | ADRB1HTR1AHTR1DHTR1BHTR3E | |
| SCHEMBL475714 | 0.79 | MAPT (0.58) | ADRB1HTR6CYP2C9 | |
| Hydrochloric Acid SCHEMBL5276815 | 0.79 | HTR6 (0.47) | ADRB1HTR1AHTR1DHTR1BHTR3E | |
| SCHEMBL475613 | 0.74 | ADRB1 (0.48) | ADRB1HTR1AHTR1DHTR1BHTR3E | |
| SCHEMBL3920646 | 0.73 | HTR6 (0.50) | ADRB1ABCB1HTR6CYP2C9HDAC6 | |
| SCHEMBL5274016 | 0.72 | ADRB1 (0.45) | ADRB1HTR1AHTR1DHTR1BHTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037925-B1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | GALENEA CORP (US) | 2012-02-01 | — | — | EP | disclosed |
| EP-2037925-A1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | Epix Delaware, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008002539-A1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | EPIX DELAWARE, INC. (US) | 2008-01-03 | — | — | WO | disclosed |