Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 8/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL475607 | 0.79 | ADRB1 (0.44) | CYP2C9HTR6ADRB1 | |
| SCHEMBL475389 | 0.78 | SMN1; SMN2 (0.74) | MAPTPOLBALDH1A1HTTCYP1A2 | |
| SCHEMBL3919058 | 0.77 | HTR6 (0.73) | MAPTPOLBALDH1A1HTTCYP1A2 | |
| Hydrochloric Acid SCHEMBL1748227 | 0.77 | SMN1; SMN2 (0.73) | MAPTPOLBALDH1A1HTTCYP1A2 | |
| Hydrochloric Acid SCHEMBL5398700 | 0.77 | HTR6 (0.71) | MAPTPOLBALDH1A1HTTCYP1A2 | |
| Tert-Butyl Formate SCHEMBL27915007 | 0.75 | SMN1; SMN2 (0.64) | MAPTPOLBALDH1A1HTTCYP1A2 | |
| SCHEMBL30267551 | 0.72 | ALDH1A1 (0.77) | MAPTPOLBALDH1A1HTTCYP1A2 | |
| SCHEMBL309940 | 0.72 | ALDH1A1 (0.77) | MAPTPOLBALDH1A1HTTCYP1A2 | |
| SCHEMBL3616361 | 0.72 | MAPT (1.00) | MAPTPOLBALDH1A1HTTCYP1A2 | |
| SCHEMBL11303513 | 0.70 | MAPT (0.60) | MAPTPOLBALDH1A1HTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037925-B1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | GALENEA CORP (US) | 2012-02-01 | — | — | EP | disclosed |
| EP-2037925-A1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | Epix Delaware, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008002539-A1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | EPIX DELAWARE, INC. (US) | 2008-01-03 | — | — | WO | disclosed |