Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 4/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.39 |
| ▸ | KDM6B | O15054 | 5/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4756158 | 0.78 | L3MBTL1 (0.46) | KDM4EGLAALDH1A1KIF11SIRT2 | |
| SCHEMBL1523353 | 0.75 | KDM4C (0.62) | MAPK8MAPK9MAPK10KDM4EGLA | |
| SCHEMBL4292881 | 0.75 | SIRT2 (0.42) | KDM4EALDH1A1KIF11SIRT2HPGD | |
| SCHEMBL4295736 | 0.74 | SIRT2 (0.43) | KIF11SIRT2 | |
| SCHEMBL4288183 | 0.74 | HCAR3 (0.49) | KDM4EKIF11SIRT2KMT2A | |
| SCHEMBL21767777 | 0.73 | KDM4E (0.53) | MAPK8MAPK9MAPK10KDM4EGLA | |
| SCHEMBL4290857 | 0.72 | AGTR1 (0.47) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL4297412 | 0.71 | AGTR1 (0.42) | KDM4EKIF11SIRT2HSD17B10TSHR | |
| SCHEMBL4301697 | 0.70 | AGTR1 (0.41) | KDM4EKIF11SIRT2HSD17B10TSHR | |
| SCHEMBL14874214 | 0.70 | KDM4E (0.59) | MAPK8MAPK9MAPK10KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896048-A2 | PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE (PACAP) RECEPTOR (VPAC2) AGONISTS AND THEIR PHARMACOLOGICAL METHODS OF USE | Bayer Pharmaceuticals Corporation (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006121588-A2 | PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE (PACAP) RECEPTOR (VPAC2) AGONISTS AND THEIR PHARMACOLOGICAL METHODS OF USE | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-11-16 | — | — | WO | disclosed |