Sugi Predict

Sugi Predict / Compounds / SCHEMBL4756430

SCHEMBL4756430

SCHEMBL4756430

O=Cc1ccc(CN2CCN(C(=O)O)CC2)cc1

nearest known ligand 0.52

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ FAAH O00519 1/20 0.52
▸ HRH3 Q9Y5N1 1/20 0.51
▸ GPR183 P32249 6/20 0.50
▸ KMT2A Q03164 2/20 0.50
▸ MEN1 O00255 1/20 0.50
▸ ALDH1A1 P00352 4/20 0.49
▸ LMNA P02545 3/20 0.49
▸ SMN1; SMN2 Q16637 2/20 0.49
▸ KDM4E B2RXH2 1/20 0.48
▸ HPGD P15428 1/20 0.47
▸ HTT P42858 1/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27990811 0.86 HRH3 (0.52) FAAHHRH3ALDH1A1LMNASMN1; SMN2
SCHEMBL15652992 0.86 HRH3 (0.71) FAAHHRH3GPR183KMT2AMEN1
SCHEMBL20179983 0.84 ALDH1A1 (0.50) FAAHHRH3GPR183KMT2AMEN1
SCHEMBL23086975 0.84 ALDH1A1 (0.50) FAAHHRH3GPR183KMT2AMEN1
SCHEMBL13582645 0.82 FAAH (0.54) FAAHHRH3GPR183KMT2AMEN1
SCHEMBL13582644 0.82 FAAH (0.54) FAAHHRH3GPR183KMT2AMEN1
SCHEMBL2931705 0.81 AKR1C3 (0.65) FAAHHRH3GPR183KMT2AMEN1
SCHEMBL22346647 0.81 HRH3 (0.56) FAAHHRH3KMT2AMEN1ALDH1A1
SCHEMBL31277423 0.81 HRH3 (0.56) FAAHHRH3KMT2AMEN1ALDH1A1
SCHEMBL4158729 0.81 CA12 (0.60) FAAHHRH3KMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12281119-B2 Imidazo[2,1-f][1,2,4]triazin-4-amine derivatives as TLR7 agonist BEIGENE, LTD. (KY) 2025-04-22 — — US disclosed
EP-3921320-B1 IMIDAZO [2, 1-F] [1, 2, 4] TRIAZIN-4-AMINE DERIVATIVES AS TLR7 AGONIST BEIGENE LTD (KY) 2024-03-06 — — EP disclosed
US-20220119394-A1 IMIDAZO[2,1-F][1,2,4]TRIAZIN-4-AMINE DERIVATIVES AS TLR7 AGONIST BEONE MEDICINES I GMBH (CH) 2022-04-21 — — US disclosed
CN-113454086-A Imidazo [2,1-F ] [1,2,4] triazin-4-amine derivatives as TLR7 agonists 百济神州有限公司 2021-09-28 — — CN disclosed
WO-2009001021-A1 IMIDAZOPYRIDINE DERIVATIVES USEFUL AS ENZYME INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE AND AUTOIMMUNE DISEASES CHROMA THERAPEUTICS LTD. (GB) 2008-12-31 — — WO disclosed
EP-1963315-A2 ENZYME INHIBITORS The Institute of Cancer Research (GB) 2008-09-03 — — EP disclosed
WO-2007072017-A2 ENZYME INHIBITORS THE INSTITUTE OF CANCER RESEARCH (GB) 2007-06-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220119394-A1 IMIDAZO[2,1-F][1,2,4]TRIAZIN-4-AMINE DERIVATIVES AS TLR7 AGONIST TLR7, TLR1, TLR3 FAAH 2798/4885HRH3 324/4885GPR183 81/4885
US-12281119-B2 Imidazo[2,1-f][1,2,4]triazin-4-amine derivatives as TLR7 agonist TLR7, TLR1, TLR3 FAAH 2798/4885HRH3 324/4885GPR183 81/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.