SCHEMBL4756441

SCHEMBL4756441

O=C(Oc1ccc(-c2ccc([N+](=O)[O-])cc2[N+](=O)[O-])cc1)C(=O)Oc1ccc(-c2ccc([N+](=O)[O-])cc2[N+](=O)[O-])cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.46
GPR35 Q9HC97 2/20 0.46
MAPK1 P28482 2/20 0.46
TP53 P04637 1/20 0.46
HPGD P15428 1/20 0.46
TSHR P16473 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
MAPT P10636 4/20 0.44
GAA P10253 2/20 0.44
TDP1 Q9NUW8 2/20 0.44
KMT2A Q03164 3/20 0.43
HSPB1 P04792 1/20 0.43
MEN1 O00255 1/20 0.43
CYP1A2 P05177 1/20 0.43
HIF1A Q16665 1/20 0.42
BCL9 O00512 1/20 0.42
CTNNB1 P35222 1/20 0.42
TXNRD1 Q16881 1/20 0.41
TXNRD3 Q86VQ6 1/20 0.41
TXNRD2 Q9NNW7 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8065661 0.91 ALDH1A1 (0.46) ALDH1A1GPR35MAPK1TP53HPGD
SCHEMBL4667166 0.80 ALDH1A1 (0.58) ALDH1A1GPR35MAPK1TP53HPGD
SCHEMBL11781006 0.79 TDP1 (0.61) ALDH1A1GPR35MAPK1TP53HPGD
SCHEMBL7063519 0.79 GAA (0.65) ALDH1A1MAPK1SMN1; SMN2MAPTGAA
SCHEMBL28244181 0.78 ALDH1A1 (0.56) ALDH1A1GPR35MAPK1TP53HPGD
SCHEMBL9798383 0.78 MAPK1 (0.62) ALDH1A1GPR35MAPK1TP53HPGD
SCHEMBL9797785 0.78 ALDH1A1 (0.62) ALDH1A1GPR35MAPK1TP53HPGD
SCHEMBL4667304 0.77 CA2 (0.65) ALDH1A1GPR35MAPK1TP53HPGD
SCHEMBL28366256 0.76 ACHE (0.57) ALDH1A1GPR35MAPK1TP53HPGD
SCHEMBL10711868 0.76 TDP1 (0.59) ALDH1A1GPR35MAPK1TP53HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008147381-A1 DETECTION OF PEROXIDE-BASED EXPLOSIVES USING CHEMILUMINESCENCE REDXDEFENSE, LLC (US) 2008-12-04 WO disclosed