Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | EDNRB | P24530 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.42 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4756572 | 0.77 | TTR (0.43) | MAPK1KDM4E | |
| SCHEMBL4753206 | 0.76 | MAPK1 (0.45) | MAPK1MAPTKMT2AMEN1 | |
| SCHEMBL4755109 | 0.72 | SMN1; SMN2 (0.44) | ALDH1A1MAPTHPGDKMT2AMEN1 | |
| SCHEMBL4756548 | 0.72 | GAA (0.46) | ALDH1A1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL3034631 | 0.70 | ALDH1A1 (0.47) | ALDH1A1MAPK1KDM4EMAPTHPGD | |
| Piperonylic Acid SCHEMBL142318 | 0.70 | ALDH1A1 (1.00) | ALDH1A1MAPK1KDM4EMAPTHPGD | |
| Piperonylic Acid SCHEMBL31119409 | 0.70 | ALDH1A1 (1.00) | ALDH1A1MAPK1KDM4EMAPTHPGD | |
| Piperonylic Acid SCHEMBL3946119 | 0.70 | ALDH1A1 (1.00) | ALDH1A1MAPK1KDM4EMAPTHPGD | |
| SCHEMBL4756539 | 0.69 | PTGFR (0.41) | ALDH1A1MAPK1KDM4EHPGDKMT2A | |
| Piperonylic Acid SCHEMBL1184937 | 0.69 | ALDH1A1 (0.96) | ALDH1A1MAPK1MAPTHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | claimed |
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | disclosed |