Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HPD | P32754 | 5/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4756539 | 0.81 | PTGFR (0.41) | NPC1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4756572 | 0.76 | TTR (0.43) | KDM4EHPD | |
| SCHEMBL4753206 | 0.74 | MAPK1 (0.45) | MEN1MAPTKMT2AHPD | |
| SCHEMBL4755109 | 0.73 | SMN1; SMN2 (0.44) | ALDH1A1MEN1MAPTKMT2ATDP1 | |
| SCHEMBL4756570 | 0.72 | ALDH1A1 (0.50) | POLBALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL4503339 | 0.69 | NPC1 (0.70) | NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL31022695 | 0.69 | MEN1 (0.62) | NPC1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL758991 | 0.69 | MEN1 (0.62) | NPC1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL25078424 | 0.69 | GAA (0.51) | GAAPOLBNPC1ALDH1A1CREBBP | |
| SCHEMBL16755418 | 0.68 | NPC1 (0.48) | POLBNPC1ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | claimed |
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | disclosed |