Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | AHCY | P23526 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499588 | 0.96 | IDO1 (0.39) | IDO1RENALDH1A1HPGDHTT | |
| SCHEMBL8080309 | 0.86 | NOS2 (0.41) | RENALDH1A1HPGDHTTNOS2 | |
| SCHEMBL499262 | 0.86 | NOS2 (0.41) | RENALDH1A1HPGDHTTNOS2 | |
| SCHEMBL4754043 | 0.85 | SLC6A4 (0.40) | IDO1RENHTTNOS2MAPT | |
| SCHEMBL499150 | 0.83 | MAPT (0.38) | IDO1MAPTAHCYKDM4E | |
| SCHEMBL499213 | 0.82 | UTS2R (0.35) | IDO1MAPTAHCYKDM4E | |
| SCHEMBL498921 | 0.81 | REN (0.39) | IDO1RENHTTMAPTSMN1; SMN2 | |
| SCHEMBL499264 | 0.81 | REN (0.39) | IDO1RENHTTMAPTSMN1; SMN2 | |
| SCHEMBL498979 | 0.79 | UTS2R (0.33) | ALDH1A1HPGDMAPTAHCYKDM4E | |
| SCHEMBL4755992 | 0.78 | NOS2 (0.43) | ALDH1A1HPGDHTTNOS2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156816-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |