Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 5/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.31 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | AHCY | P23526 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499150 | 0.87 | MAPT (0.38) | UTS2RPDK2MAPTKDM4EGAA | |
| SCHEMBL499213 | 0.86 | UTS2R (0.35) | UTS2RPDK2MAPTKDM4EGAA | |
| SCHEMBL499588 | 0.82 | IDO1 (0.39) | UTS2RMAPTALDH1A1KDM4EAHCY | |
| SCHEMBL498970 | 0.81 | UTS2R (0.34) | UTS2RMAPTALDH1A1KDM4EGAA | |
| SCHEMBL4756782 | 0.79 | IDO1 (0.37) | MAPTALDH1A1KDM4EAHCYHPGD | |
| SCHEMBL499662 | 0.78 | MAPT (0.38) | UTS2RPDK2MAPTALDH1A1KDM4E | |
| SCHEMBL4755910 | 0.78 | KDM4E (0.33) | MAPTALDH1A1KDM4EGAAPKM | |
| SCHEMBL4757403 | 0.75 | MAPT (0.42) | UTS2RMAPTALDH1A1KDM4EGAA | |
| SCHEMBL8561372 | 0.73 | F2R (0.34) | KAT6AKAT5ALDH1A1 | |
| SCHEMBL31462722 | 0.72 | AOC3 (0.39) | UTS2RPDK2KDM4EAHCY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106221-B2 | Renin inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2012-01-31 | — | — | US | disclosed |
| US-20100144825-A1 | Renin Inhibitors | VITAE PHARMACEUTICALS, INC. | 2010-06-10 | — | — | US | disclosed |
| WO-2008156816-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144825-A1 | Renin Inhibitors | ACE, REN, DNPEP | UTS2R 520/4885PDK2 2610/4885MAPT 935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.