Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 15/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | EBP | Q15125 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4756747 | 0.81 | CHRM3 (0.47) | CHRM3CHRM2CHRM1KCNA3CYP2D6 | |
| SCHEMBL4758052 | 0.79 | DRD2 (0.42) | CHRM3CHRM2CHRM1CCR1KCNA3 | |
| SCHEMBL4757548 | 0.78 | CHRM3 (0.46) | CHRM3CHRM2CHRM1CCR1EBP | |
| SCHEMBL4755540 | 0.74 | CCR1 (0.41) | CHRM3CHRM2CHRM1CCR1KCNA3 | |
| SCHEMBL13271382 | 0.74 | CYP2D6 (0.44) | CHRM3CHRM2CHRM1CCR1EBP | |
| SCHEMBL10747164 | 0.73 | CHRM3 (0.40) | CHRM3CHRM2CHRM1CCR1EBP | |
| SCHEMBL11630708 | 0.68 | CCR1 (0.45) | CHRM3CHRM2CHRM1CCR1KCNA3 | |
| SCHEMBL11650019 | 0.68 | SIGMAR1 (0.46) | CHRM3CHRM2CHRM1CCR1EBP | |
| SCHEMBL14541984 | 0.67 | EBP (0.51) | CHRM3CHRM2CHRM1CCR1KCNA3 | |
| SCHEMBL4756753 | 0.67 | CHRM3 (0.50) | CHRM3CHRM2CHRM1CYP2D6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124575-A1 | RENIN INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-16 | — | — | WO | claimed |
| WO-2008117229-A1 | MUSCARINIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2008-10-02 | — | — | WO | claimed |
| WO-2008117229-A1 | MUSCARINIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2008-10-02 | — | — | WO | disclosed |