Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 13/20 | 0.48 |
| ▸ | GSK3B | P49841 | 9/20 | 0.48 |
| ▸ | KAT5 | Q92993 | 3/20 | 0.43 |
| ▸ | KAT7 | O95251 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | WNT1 | P04628 | 4/20 | 0.38 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | CLK3 | P49761 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4756995 | 0.83 | DYRK1A (0.47) | DYRK1AGSK3BKAT5KAT7MAP4K4 | |
| SCHEMBL6760162 | 0.75 | USP2 (0.45) | DYRK1AGSK3BKAT5KAT7MAP4K4 | |
| SCHEMBL4757789 | 0.74 | KAT6A (0.42) | KAT5KAT7KDM4EALDH1A1GAA | |
| SCHEMBL2635338 | 0.70 | KDM4E (0.61) | KDM4EALDH1A1GAA | |
| SCHEMBL21638091 | 0.70 | KDM4E (0.61) | KDM4EALDH1A1GAA | |
| SCHEMBL6755660 | 0.69 | DYRK1A (0.38) | DYRK1AGSK3BKAT5KDM4EALDH1A1 | |
| SCHEMBL4757784 | 0.69 | CALCRL (0.53) | DYRK1AGSK3BKAT5KAT7 | |
| SCHEMBL6756716 | 0.68 | FYN (0.54) | DYRK1AGSK3BMAP4K4 | |
| SCHEMBL17149168 | 0.67 | USP2 (0.46) | DYRK1AGSK3BKAT5WNT1CLK2 | |
| SCHEMBL27181183 | 0.67 | ALDH1A1 (0.57) | KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009000819-A1 | 5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009000819-A1 | 5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | WO | disclosed |